Additionally, miRNA interaction with PAK1 expression has been described previously: in hepatocellular carcinoma development, miRNA-485-5p was observed to suppress PAK1 levels, and lncRNA-mediated binding of miRNA-485-5p resulted in the upregulation of PAK1 during hepatocellular carcinoma progression [84]. This evidence concerns the gene PAK1 and hepatocellular carcinoma.