CASP3 and liver cancer: Through the PI3K-AKT signaling pathway, EGCG do COX-2wn-regulates cyclooxygenase-2 (COX-2), activates caspase-3 and caspase-9, induces the apoptosis of liver cancer cells, inhibits the activity of matrix metalloproteinase (MMP)-2 and MMP-9, promotes the apoptosis of B-lymphoma cells, downregulates the expression levels of PI3K and AKT/NF-κB, and makes the liver cancer cell SMMC7721 stagnate in the S phase [53].