VEGFA and central nervous system cancer: Sun et al. studied the angiogenesis phenomena in gliomas and revealed that EVs (produced from GSCs), which transport miRNA encoded by the MIR21 gene (miR-21), increase endothelial cells migration and tubular structure formation; he reinforced this statement by showing that the suppression of VEGF leads to the reduction in endothelial cells tube formation, implying the VEGF involvement in the mediation of miR-21-associated neo-angiogenesis [30].