Evidence has demonstrated a positive loop between astrocytes and microglia at the tumor site: the microglial cells release IL-6 that activates the peri-tumoral reactive astrocytes to secrete Monocyte Chemotactic Protein-3 (MCP-3) via JAK-STAT proteins, which further attracts more microglial cells [125]. The gene discussed is SOAT1; the disease is neoplasm.