IL-6, secreted by glioma-associated astrocytes, promotes the activation of proteolytic enzymes, the MMPs (including gelatinases MMP-2, MMP-9, and MMP-14) involved in tumor invasion and metastasis, by the remodeling of the extracellular matrix and the degradation of type IV collagen of the endothelial basement membrane [146]. The gene discussed is MMP2; the disease is neoplasm.