The interactions of APOD with multiple key pathways may be responsible for its effects in BC, including the estrogen receptor (ER), mitogen-activated protein kinase (MAPK), progesterone receptor (PR), cyclo-oxygenase-2 (COX-2), and 5-lipoxygenase (5-LO) pathways [101,102,103,104,105]. This evidence concerns the gene ESR1 and breast cancer.