NOTCH1 and neoplasm: Because NOTCH1 signaling is involved in the regulation of the vascular architecture of the TME, activation of CD8+ cytotoxic T cells as well as guiding differentiation of tumor-associated macrophages (TAMs) [15,34,36], interactions of the immune system and NOTCH1 were investigated with the immunoscore, which is based on the infiltration of CD3+ and CD8+ T lymphocytes in the core and the invasive margin of the tumor.