Furthermore, some of the genes were described as important regulators during PDAC development and progression; e.g., KMT2C/myeloid/lymphoid or mixed-lineage leukemia protein 3 (MLL3) is a histone methyltransferase [34] and chromatin modifier with a large impact on the expression of chromatin-regulating genes and genes involved in cell proliferation [35], suggesting that MLL defects likely cause global epigenetic alterations that support tumor development. This evidence concerns the gene PRDM9 and neoplasm.