PBRM1 and nonpapillary renal cell carcinoma: According to our previous study, category 3 of the vascularity-based architectural classification, which is related to loss of PBRM1 expression, was significantly associated with an inflamed and excluded immunophenotype in the localized ccRCC cohort and significantly enriched in effector-T cell and immune checkpoint gene signatures in the TCGA-KIRC cohort [15].