In contrast, tumors characterized by high-grade and aggressive behavior include multiple clonal drivers that exhibit truncal aberrations of ccRCC epigenetic-related genes: the SWI/SNF chromatin remodeling complex gene PBRM1, histone deubiquitinate gene BAP1, and histone methyltransferase gene SETD2 [8,26]. This evidence concerns the gene PBRM1 and nonpapillary renal cell carcinoma.