PIK3CA and thyroid cancer: The co-culture of thyroid cancer cell lines with M2-like TAMs facilitates dedifferentiation, proliferation, migration and invasion in thyroid cancer cells through the Wnt/ß-catenin pathway activation by Wnt1 and Wnt3a secretion [48] but also through insulin-like growth factor (IGF) secretion which promotes thyroid cancer stemness and metastasis by activating the PI3K/AKT/mTOR pathway [48].