AVP and clostridium difficile infection: Moreover, CDI symptoms may vary according to whether the impairment affects one or more of the hypothalamic-posterior pituitary sites involved in ADH secretion (i.e., the hypothalamic osmoreceptors, the supraoptic or paraventricular nuclei, or the superior portion of the supra-opticohypophyseal tract) [20,32,33,34,35].