PD-L1 combined positive score (CPS), which has been defined as number of PD-L1-positive cells, including tumor cells, macrophages, and lymphocytes, divided by the total number of tumor cells and multiplied by 100, is currently used for selection of ICIs in several malignancies such as AGC [15,33,34,35,36,37,38]. This evidence concerns the gene CD274 and neoplasm.