Furthermore, upregulation of YAP/TAZ by a stiff matrix contributes to cancer progression via proliferation and drug resistance in mammary epithelial/cancer cells [40,70,87], proliferation and EMT in pancreatic cancer cells [23,71], proliferation in colorectal cancer cells [50], growth of lung cancer cells [51], drug resistance, migration, proliferation, EMT, and stemness in HCC cells [55,56,91], and migration and invasion of prostate cancer cells [90]. This evidence concerns the gene WWTR1 and familial pancreatic carcinoma.