A stiff matrix induces the nuclear localization and/or expression of YAP/TAZ followed by transcriptional regulation in mammary epithelial/cancer cells [40,41,70,86,87,88], cervical cancer cells [86], pancreatic cancer cells [23,71], colorectal cancer cells [50], lung cancer cells [51,90], hepatocellular carcinoma cells [55,56,91], ovarian cancer cells [58], melanoma cells [92], osteosarcoma cells [93], and prostate cancer cells [90]. Here, WWTR1 is linked to Familial prostate cancer.