The SRY-box transcription factor 2 (SOX2) is upregulated for the induction of stemness by stiff matrix in HCC cells [80], whereas SOX2 expression is induced by a soft matrix for drug resistance to apoptosis in laryngeal squamous cell carcinoma cells [72], suggesting a cell type-dependent response of SOX2 to matrix stiffness. Here, SOX2 is linked to laryngeal squamous cell carcinoma.