The stiff matrix promotes the expression of C-X-C motif chemokine receptor 4 (CXCR4) and decreases the level of ubiquitin domain-containing protein 1 (UBTD1), which is involved in the proteasome-dependent degradation of YAP, and finally enhances YAP activity in cancer cells [90,91]. This evidence concerns the gene UBTD1 and cancer.