CD274 and non-small cell lung carcinoma: Similarly, using the Flatiron Health database, with a median follow-up of approximately 7 months, Waterhouse et al. [35] estimated median rwToT with first-line ICI monotherapy of 4.3 and 4.4 months for squamous and nonsquamous advanced NSCLC, respectively (70% of 3041 patients with PD-L1 ≥ 50%; 53% with ECOG PS of 0–1).