Jiang et al. suggested that the MMR system is strongly associated with the curcumin response in LS CRC [50]; in their study, an elevated cytotoxic response to curcumin was observed in MLH1-deficient HCT116 and RKO cells as well as in MSH2-deficient Hec59 cells compared to matching MMR-proficient HCT116+ch3, RKO+MLH1, and Hec59+ch2 cells [50]. This evidence concerns the gene MSH2 and Leigh syndrome.