Wei et al. observed a potent apoptosis-inducing ability of curcumin on the MMR-deficient CRC cell lines HCT116, LoVo, SW48, and HCT15, but their study lacked proper MMR-proficient controls; thus, a higher sensitivity of MMR-deficient CRC cell lines cannot be concluded [49]. The gene discussed is MRC1; the disease is colorectal carcinoma.