ERBB2 and colorectal carcinoma: Following the success of the HER2-targeting mAb trastuzumab conjugated with the DNA topoisomerase I inhibitor deruxtecan (together known as ENHERTU) in the phase 2 DESTINY-Breast01 trial, this therapy was evaluated in several other types of solid tumors [113] including CRC (DESTINY-CRC01 [114].