The spectrum of actionable genomic targets in CCA embraces various kinases (FGFR1, FGFR2, FGFR3, PIK3CA, ALK, EGFR, ERBB2, BRAF and AKT3), oncogenes (IDH1, IDH2, CCND1, CCND3 and MDM2) and tumor-suppressor genes (BRCA1 and BRCA2) [26]. The gene discussed is IDH1; the disease is cholangiocarcinoma.