Moreover, elevated serum level of nardilysin (N-arginine dibasic convertase, NRDC), a soluble cytosolic protein, correlated with increased NRDC mRNA expression in tumor tissue and EMT-inducing transcription factors, and was associated with shorter OS and DFS in patients with iCCA [87]. The gene discussed is NRDC; the disease is infantile convulsions and choreoathetosis.