Clark et al. noted that immunosuppression in PDAC is associated with the presence of tumour-promoting immune cells rather than inflammatory cells [89], whereas, patients with a higher mortality in PDAC exhibited a low T-cell infiltration with a secretion of CXCL12 chemokine and CAF expression of fibroblast activation protein (FAP) [88]. Here, CXCL12 is linked to neoplasm.