EGF and neoplasm: For example, macrophages co-cultured with breast cancer cells in a more in vivo-like environment led to a significant increase in oxygen consumption as well as in the secretion of epidermal growth factor (EGF) and IL-10, suggesting a synergistic crosstalk between different types of cells and indicating a tumor-promoting activity of immune cells colonizing tumors such as M2-polarized macrophages [170].