A search against COSMIC [48] identified a number of mutations found in tumors (i.e. adenocarcinoma, squamous cell carcinoma, malignant melanoma and clear cell renal cell carcinoma) localizing within fragments corresponding to SPATA22, ZBTB17, CCT7, MAP1S and PDIA3 proteins. The gene discussed is PDIA3; the disease is clear cell renal carcinoma.