The t(11;18)(q21;q21) translocation, a trigger for NF-κB activation, was more frequently observed in cases of HP-negative MALT lymphoma than in those of HP-positive MALT lymphoma, and NF-κB signaling contributes to the antibiotic unresponsiveness of gastric MALT lymphoma [13,42,43,118,119]. The gene discussed is NFKB1; the disease is MALT lymphoma.