Histopathological examination showed cutaneous mucinous adenocarcinoma with positive surgical margins and the following immunohistochemical stains: ER(+), PGR(+), PAS (+) alcian blue (+), CK7(+), CK AE1/3(+), CK20(−), CEA(+), EMA(+), GCDFP-15(+/−), synaptophysin(+), chromogranin(−), CD56(−), TTF-1(−), and CK 5/6 with p63 (+) in cells surrounding the neoplastic nests. Here, ESR1 is linked to mucinous adenocarcinoma.