To address the role of uPAR in neuroblastoma growth and metastasis in vivo, we mixed Neuro2a WT or Neuro2a-shuPAR cells, both expressing GFP as a reporter, with Matrigel and injected the mixture subcutaneously into mice to evaluate the tumor growth and lung metastasis three weeks later (Figure 5). This evidence concerns the gene PLAUR and neuroblastoma.