Many factors inactivated in BC, including BRCA1, BRCA2, ATM, BARD1, BRIP1, CHK1, CHK2, ABRAXAS1, MRE11, Nibrin, PALB2, RAD50, RAD51C and RAD51D, are involved in the repair of DSBs by HR [12]. Here, BRCA1 is linked to breast cancer.