HIF1A and adrenal cortex carcinoma: Yu et al. found the expression of p-S6 (downstream molecule of mTOR), p-Stat3, PAI, EGFR and HIF-1a was significantly increased in 72 ACC samples, compared with 12 pleomorphic adenoma and 18 normal salivary glands tissues, suggesting possible mTOR downstream inhibitors as ACC therapy targets [73].