Moreover, in human neuroblastoma cells, TRIM32 is recruited to the spindle poles by CDK1/cyclin B-mediated phosphorylation where it interacts with MYCN during mitosis, facilitating its proteasomal degradation, inducing asymmetric cell division and suppressing sphere formation of neuroblastoma-initiating cells [88,89]. The gene discussed is TRIM32; the disease is neuroblastoma.