For example, Ino et al. showed that the ratio of Tregs to CD4+ T cells (% Tregs) or higher levels of M2 macrophages within the TME are associated with shorter survival, while higher levels of tumor-infiltrating CD4+ T and CD8+ T cells, or the ratio of M1 macrophages to pan-macrophages (% M1) correlate with longer survival [107]. The gene discussed is CD4; the disease is neoplasm.