In line with the BV173 results, PDX engrafted female NSG mice developed aggressive leukemia associated with reduced heart size and weight, reduced cardiomyocyte CSA, impaired LV function, increased amount of TUNEL+ cardiac cells and cardiac BNIP3 expression (Figure S1b–h, File S1, Table 2). The gene discussed is BNIP3; the disease is leukemia.