Certain methylation markers specifically associated with lung cancer progression and metastasis, such as increased methylation of DAL-1, EPHB6, HS3ST2, TMEM88 and MGMT, and decreased methylation of ELMO3, are linked to higher rates of metastasis in NSCLC [29,30,31,32,33,34]. Here, MGMT is linked to non-small cell lung carcinoma.