Gao et al. showed that smoking is associated with hypomethylation (KLF6, TERT, MSH5, ACTA2, GATA3, and VTI1A) and hypermethylation (STK3A and CHRNA5) of genes related to lung cancer susceptibility [156], suggesting they might be regulated by DNAm. The gene discussed is TERT; the disease is lung cancer.