These genes play crucial roles in cellular functions that are often dysregulated in cancer, including apoptosis (CASP8, DAPK, TNFRSF6, DR4, DR5) [88,89,90,91], cell cycle regulation (CDKN2A/p16, PTEN, RASSF1A) [91,92,93,94,95,96], DNA repair (MGMT, MLH1, MSH2) [97,98], regulation of signaling pathway (APC, RARβ-2, RUNX3, SHOX2) [96,99,100,101,102], and cell adhesion and invasion (CDH1, CDH13, TSLC1) [103,104] (Table 1). The gene discussed is CDKN2A; the disease is cancer.