A recent genome-wide study identified 20 potential hypermethylated driver genes (e.g., SLIT2, CDO1, TCF21, PCHD17, IRX1, HSPB6, and TBX5) and 13 methylation-driver non-coding RNAs in NSCLC [128]. This evidence concerns the gene TCF21 and non-small cell lung carcinoma.