Further we analyzed percentage alteration frequency of different genetic and transcriptional alterations of PIK3C2B pathway elements such as AKT1, AKT2, AKT3, PIK3C2B, PIP5K1A, PIP5K1B, PIP4K2A, PIP4K2B, and PI4KB, etc., in HGSOC tissues and other cancer tissues and PIK3C2B protein abundance using cBioPortal and TCGA datasets. The gene discussed is AKT1; the disease is cancer.