In the pivotal two European and US studies reported by Tiacci et al. [9] in 2015, overall, 54 BRAF-mutated HCL patients relapsed and/or refractory to purine analogue-based treatments received vemurafenib at the standard melanoma dose of 960 mg b.i.d. for a median of 16 weeks and 18 weeks, respectively (Table 3). This evidence concerns the gene BRAF and melanoma.