CDH1 and hepatocellular carcinoma: Studies in well differentiated human HCC tumors indicate that E-cadherin is localized to the plasma membrane, whereas poorly differentiated HCC tissues have cytoplasmic dislocation or a frequent loss of E-cadherin and nuclear accumulation of β-catenin, reflecting, in large part, the progressive nature of EMT during the course of multistep hepatocarcinogenesis [237,238].