Experimental evidence indicates that tumor-derived TGF-β can feed signals to HSCs and induce the expression of ADAMs, a family of transmembrane and secreted proteins with metalloendopeptidase activity, and the secretion of tissue inhibitors of metalloproteinases (TIMPs), as well as the CCL and CXCL family of chemokines [277,278]. The gene discussed is TGFB1; the disease is neoplasm.