However, with the current understanding of recent research in the field, it is possible to conclude that m6A modifications and the TGF-β signaling axis are involved in a variety of complex downstream mechanisms that intrinsically contribute to the hallmarks of HCC, including increased cell proliferation, evasion of apoptosis, the induction of EMT, invasion, and metastatic pathways [232]. This evidence concerns the gene TGFB1 and hepatocellular carcinoma.