TGFB1 and neoplasm: When portrayed in this way, genomic and transcriptomic perturbations in TGF-β signaling components, rewiring of the transcriptional responses of intracellular signaling circuitry, and defective cytostatic and proapoptotic processes may individually or collectively decouple TGF-β from tumor-suppressive outcomes and instead provide functional capabilities to switch the responses towards the activation of the pro-tumorigenic arm.