In this context, Smad-interacting transcriptional corepressors, such as Zeb2, Hey2, and serum response factor (SRF), whose expression is upregulated in HCC tumors and cell lines, can neutralize the TGF-β-induced transcriptional stimulation of p15INK4b and p21CIP1, as well as the suppression of c-Myc [8,188,189,190]. This evidence concerns the gene CDKN1A and hepatocellular carcinoma.