We hypothesize this to be related to the different duration-related mechanisms-of-action of each therapy: while the prolonged use of denosumab directly eliminates RANK-positive reactive giant cells and makes stromal tumor cells quiescent during its whole therapeutic course, radiotherapy and SAE, performed in single or in a limited number of procedures, indirectly and temporarily reduce tumor nutrition and cellular activity, likely capable of regrowing and/or metastasizing [8,10,47]. Here, TNFRSF11A is linked to neoplasm.