Compared to the monoculture, cytokine-induced genes were generally upregulated for MM cells from the upper transwell (Supplementary Figure S2C); similar results were obtained when another two sets of IL6-induced genes were considered, one for INA-6 [28] (Supplementary Figure S2D) and another for ANBL-6 [29] (Supplementary Figure S2E).Therefore, the BMSC-induced transcriptome signatures of MM cells defined in our work were validated by gene expression data published by others [27,28,29,30,31]. Here, IL6 is linked to Miyoshi myopathy.