TNF and Miyoshi myopathy: As expected [8], results from GSEA [24] against MSigDB hallmark gene sets [25] revealed that soluble factors upregulated several signaling pathways including IL6/JAK2/STAT3 with leading genes including SOCS3 and STAT3, TNFα signaling via NFκB, and an interferon γ response (Figure 2A), as well as unfolded protein response genes for MM cells (Figure 2B).