IFNA1 and hemophagocytic syndrome: For example, while proper IFN signaling is crucial to regress tumor formation [13], aberrant IFN signaling is detrimental in systematic lupus erythematosus [14] and in cytokine storm-associated diseases such as sepsis, hemophagocytic lymphohistiocytosis, and SARS-CoV-2 infection [15,16].