Surprisingly, SOX9 overexpression did not alter the expression of SNAIL or other well-known EMT transcription factors such as SLUG or ZEB1 in BxPC-3 and IMIMPC-2 pancreatic cancer cells (Figure 2A; Supplementary Figure S2B); however, the expression of the BMI1 stem cell factor was elevated (Figure 2A). This evidence concerns the gene SNAI2 and familial pancreatic carcinoma.