These tumor-associated glycan structures can be present on the surface of cancer cells, but they can be also secreted or shed into the circulation and, thus, serve as potential biomarkers of disease (such as SLea serologically detected by CA19-9, STn detected by CA72-4, MUC16 detected by CA125 and MUC1 detected by CA15-3) [13]. This evidence concerns the gene MUC16 and neoplasm.