Though not directly a DNA repair protein, therapeutic inhibition of the nucleotide salvage protein DNPH1 also improved responses to PARP-inhibition in BRCA-mutated tumor cells, and was able to overcome acquired resistance to PARP inhibition when combined with the cytotoxic nucleotide 5-hydroxymethyl-deoxyuridine [68]. This evidence concerns the gene PARP1 and neoplasm.