In the initial phase of development of cell resistance to cisplatin and other chemotherapeutics, which in our model, was triggered by cancer cell exposure to the alkylating drug, acetyltransferase is recruited to the gene promoter of ABCC10, where it facilitates gene expression and maintains it at a higher level in drug-resistant cells, which are generally characterized by EP300-enriched chromatin. Here, EP300 is linked to cancer.