Collectively, in vitro studies and clinical specimen analysis of cancer genome database have revealed a microRNA-informed epigenetic signature that can identify a subset of high-risk PCa patients who are likely to show improved response to immunotherapy with a treatment plan that includes intercepting the VEGF/VEGFR regulated angiogenesis pathway with a drug such as sunitinib. The gene discussed is KDR; the disease is posterior cortical atrophy.