For example, PARP-1 is recruited to AR-occupied genomic sites in PCa cells [44]; PARP-2, a PARP-1 paralog, enhanced AR activity by interacting with chromatin-bound FOXA1, a pioneering factor that promotes AR-mediated target transcription [45]; and a functional HRR pathway requires AR activity [46,47,48]. Here, PARP1 is linked to posterior cortical atrophy.