Data documented that CML LSCs CD34+/CD38− exhibited the expression of a profile CD25+/CD26+/CD56+/CD93+/IL-1RAP+ in contrast with the AML LSCs profile only characterized by CD25+/CD96+/IL-1RAP+ and CD371+, without the expression of CD26, with the exception of the subgroup of AML FLT3-ITD+. This evidence concerns the gene CD96 and acute myeloid leukemia.