Other glioma research has shown that CBD inhibits U87-MG and T98G glioma cell proliferation and invasiveness, and can downregulate ERK and Akt pro-survival signalling pathways and decrease hypoxia inducible factor HIF-1α expression in U87-MG cells (HIF-1α is a critical regulator of the hypoxic response, upregulating cell survival associated molecules, promoting invasion and tumour angiogenesis and the switch to glycolytic metabolism) [106]. This evidence concerns the gene AKT1 and central nervous system cancer.