Inhaled CBD limited tumour growth and altered the dynamics of the tumour microenvironment: it repressed P-selectin (which, in cancer, helps tumours metastasise and become treatment resistant), apelin (elevated in glioblastoma, acting to support blood vessel growth and promote cancer stem cells), and interleukin (IL)-8 (typically secreted by glioblastomas to promote cell migration and angiogenesis and found to be elevated in many forms of cancer) [113]. This evidence concerns the gene APLN and glioblastoma.