ALB and cancer: Based on previous evidence on the capability of PTX2S/Pba untargeted NPs to be efficiently and specifically activated in the reductive environment of cancer cells, in turn promoting micelle disassembly and Pba release [30], we investigated the antitumor efficacy of our chemotherapy/PDT approach using PEGylated and HSA-targeted nanoparticles containing Pba and two different PTX prodrugs, i.e., PTX2S and MAL.