HMGCR and neoplasm: Furthermore, the combined drugs aimed at the same action mechanisms, as the alkylating agent (CP), or other actions as antimetabolites (CAP, 5-FU, and actinomycin-D), antimicrotubular (PTX), antifungal (allicin), HMG-CoA reductase inhibitors (simvastatin), antioxidants (CoQ10 and Res), antibody (BEV), topoisomerase I inhibitor (CPT-11), and microRNA (Anti-miR363), that influence tumor development in different ways.