Yan et al. found that upregulation of hsa_circ_0035483 promotes the drug resistance of renal cancer cells to gemcitabine, mainly hsa_circ_0035483 sponging hsa-miR-335, resulting in upregulated expression of Cyclin B1 (CCNB1) and thus promoting tumor growth and autophagy induced by gemcitabine in renal cancer cells [46]. Here, CCNB1 is linked to renal carcinoma.