Mechanistically, the authors delineated a novel circ_0001666/miR-1251/SOX4 regulatory axis in pancreatic cancer cells, whereby the oncogenic effects of circ_0001666 were rescued by miR-1251 overexpression and inhibited SOX4 expression in both in vitro and in vivo experiments [82]. This evidence concerns the gene SOX4 and pancreatic neoplasm.