In R/R DLBCL, the results of efficacy with BTKi in monotherapy have been modest, with ORR of 38% in ABC-DLBCL (5% in GCB-DLBCL) with ibrutinib [134] or 35% with tirabrutinib, another new generation covalent BTKi [175]. Here, IBTK is linked to diffuse large B-cell lymphoma.