The multiprotein super-complex formed by MYD88-TLR9-BCR, characterized by ibrutinib responsiveness, has been shown to co-localize with mTOR on endolysosomes, where it drives pro-survival signaling in ABC-DLBCL through NF-κB and mTOR activation [44]. The gene discussed is BCR; the disease is diffuse large B-cell lymphoma.