This regional difference remained unchanged after NACT administration in both HER2+ (F/B = 9.44 ± 0.48 (interface) versus 8.02 ± 0.56 (bulk); paired t-test, p = 0.029 and TNBC tumor excisions (F/B = 9.77 ± 0.41 (interface) versus 8.37 ± 0.62 (bulk); paired t-test, p = 0.0073. This evidence concerns the gene ERBB2 and neoplasm.