The siRNA of CLIC1 enhances expression of the tumor metastasis-related genes annexin A7 and gelsolin, the knockdown of which increases CLIC1 expression in mouse HCC Hca-F and Hca-P cell lines, suggesting that CLIC1 interacts with annexin A7 and gelsolin, and mediates tumor cell migration, invasion, and metastasis [65]. This evidence concerns the gene GSN and hepatocellular carcinoma.