In addition, bestrophin-1 is also considered as a putative calcium-activated chloride channel such as TMEM16A in epithelial cells such as the cystic fibrosis pancreatic duct cell line, CFPAC-1 [24,25,26,27,28] and it enhances calcium signaling and volume regulation in CRC T-84 cells by participating in proliferation [24]. Here, ANO1 is linked to cystic fibrosis.