It could be proposed that changes in the activation of KDM2A, sirtuins SIRT1 and SIRT6 or of some other (hetero)chromatin modifiers might arise not only in the prostate cancer cells [44] but possibly mediated by exosomes in the blood of prostate cancer patients at specific stages, affecting heterochromatin structure and the expression of repeats located therein. Here, SIRT1 is linked to Familial prostate cancer.