KDM2A and Familial prostate cancer: In addition to the lysine-specific demethylase 2A (KDM2A) whose downregulation affects chromatin in prostate cancer [6], there are other (hetero)chromatin modifiers such as sirtuins, a family of NAD+-dependent deacetylases which coordinate cellular responses to different types of stress and are key players in the protection and maintenance of genomic integrity [40].