Another piece of supporting evidence from a shared genetic background concerns family Peptococcaceae; rs7574352 associated with the family Peptococcaceae [39] is located in the intergenic region in the proximity (220kb apart) of IRF1, which is involved in insulin resistance and susceptibility to T2DM, also suggested as a risk loci for PCOS [74,75]. The gene discussed is IRF1; the disease is polycystic ovary syndrome.