SETDB1 and posterior cortical atrophy: Specifically, KMT1A and KMT1E, also known as SUV39H1 and SETDB1 respectively, are upregulated in PCa cells, increasing their migration and invasion; while KMT1B (or SUV39H2) has been shown to enhance androgen-dependent activity by interacting with AR (Figure 1) [53,54].