SHQ1 and Familial prostate cancer: For instance, in an integrative genomic profiling study of prostate cancer, somatic mutations in the chromosomal 3p were identified as tumour suppressors; most importantly, SHQ1 was the only gene in the 3p region that harboured tumour associated mutations [7,30], and loss-of-function studies confirmed a tumour growth-suppressive role of SHQ1 [183].